THE SCIENCE
What is cell therapy?
Cell therapy is the transfer of intact, live cells into a patient to help lessen or cure a disease. The most common and simple type of cell therapy is a blood transfusion. Other commonly known cell therapies include red and white blood cell transfusions and bone marrow transplants.
CELL THERAPIES
Autologous vs. allogeneic cell therapies
When the cells that are used for the therapy originate from the patient, it is referred to as an 'autologous' cell therapy. When the cells that are used for the therapy originate from a donor, it is referred to as an 'allogeneic' cell therapy.
Chimeric's diversified portfolio that includes first in class autologous CAR T cell therapies and best in class allogeneic NK cell therapies.
AUTOLOGOUS THERAPIES
(Personalised)
ALLOGENEIC THERAPIES
(Off The Shelf)
CAR T EXPLAINED
What is an autologous CAR T cell therapy?
Autologous Chimeric Antigen Receptor (CAR) T cell therapy is a type of cell therapy in which a patient’s own T cells are reprogrammed in a laboratory to attack specific cancer cells.
CAR T cell therapies have shown transformative benefit in patients with blood cancers that have not responded or stopped responding to other therapies resulting in global approvals for CAR T cell therapies for certain types of Lymphoma, Leukemia and Multiple Myeloma.
How CAR-T cell therapy workS
01
Leukapheresis
Blood is drawn from a patient and transported to a manufacturer facility
02
Reprogramming
The T cells in the blood are isolated and engineered to express a CAR ( Chimeric Antigen Receptor) that is specifically designed to recognise the patient’s cancer
03
Expansion
The CAR T cells are grown in the lab until there are millions of cells, and then sent back to the patient.
04
Infusion
The CAR T cells are infused into the patient.
05
Finding cancer cells
The infused CAR T cells seek out and attach themselves to the cancer cells.
06
Cancer cell death
Once the CAR T cells have found the cancer cells and attached themselves, they send a message to destroy or kill the cancer cells.
